Co-Editor-in-Chief - Journal of Natural Products Research Updates

Michael Maes

Prof. Dr. Michael Maes is a highly cited international scientist and author (H-index=96) who published more than 600 scientific papers in peer-reviewed international journals. He gave more than 300 lectures at different international symposia. He works at different Universities all over the world in Thailand, Brazil and Australia. The work of Dr. Maes covers phenomenological and epidemiological aspects of mood disorders and the supra-multi-disciplinary field of “pathway and drug discovery processes” in depression, bipolar disorder, schizophrenia, Myalgic Encephalomyelitis / chronic fatigue syndrome (ME/CFS) and more particularly the immune-inflammatory pathways and its connections and sequels. Dr. Maes is a clinician and translational scientist whose works ranges from epidemiological and clinical research projects, case-control studies and pharmacological trials, to rodent and molecular experiments.

Dr. Maes discovered that “clinical depression” is a systemic illness characterized by peripheral a) increases in pro-inflammatory cytokine levels, an acute phase response; b) cell-mediated immune (CMI) activation; c) lowered omega-3 PUFA levels; d) lower plasma tryptophan in depression, which determines brain serotonin contents, is an inflammatory sequel and IFNα-induced depression is associated with IDO activation which is accompanied by increased synthesis of neurotoxic tryptophan catabolites.

Dr. Maes discovered that ME/CFS and depression are associated with nitrosative stress, leaky gut (increased gut permeability) and autoimmunity due to oxidative and nitrosative stress and leaky gut. Dr.Maes also develops new treatments and biomarker tools for depression and ME/CFS based on his new theories.

https://scholar.google.com.br/citations?user=1wzMZ7UAAAAJ&hl=pt-BR&oi=ao

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